Background: Exercise is the fundamental principle for preventing the peripheral arterial diseases among diabetic patients; one of these exercises is Buerger Allen exercise. Aim of the study: Was to evaluate the effect of Buerger Allen exercise on lower extremity perfusion among patients with type 2 diabetes mellitus. Design: Quasi-experimental research design was utilized to achieve the aim of this study. Setting: The study was conducted in medical department affiliated to Benha University Hospital, Egypt. Subjects: A purposive sample consisting of 60 patients with diagnosis of type 2 diabetes mellitus included in the current study and divided into two groups, study (30) and control (30). Tools: Tool (I): Patient assessment questionnaire, Tool (II): Patient knowledge assessment questionnaire, Tool (III): Patients' observational assessment and Tool (IV): Assessment of lower extremity perfusion by measuring ankle brachial index and capillary refill time. Results: There were highly statistically significant differences at (p value ≤ 0.001) between both groups regarding total knowledge and practice through the study phases compared with pre-educational program. Furthermore, post- application of Buerger Allen exercise, there were statistically highly significant difference between both groups regarding Ankle brachial index and Capillary refill time at p value<0.001 and p value 0.036 respectively compared to pre application of exercise. Conclusion: Post program implementation, there was marked improvement in total knowledge and practice level of patients in study group compared to control group. Additionally, Buerger Allen exercise implementation was effective method for improving the lower extremities perfusion among patients with type 2 diabetes mellitus. Recommendations: Encourage health care providers especially nurses to integrate Buerger Allen exercise in the care protocols of patients with diabetes mellitus in different health care settings.