Background: Menopause is a major turning point in a woman's life  and have many changes especially in mood and marital satisfaction. Aim of the study: This study aimed to evaluate the effectiveness of psycho-educational program on depressive symptoms and marital satisfaction among menopausal women. Design: A quasi-experimental design two-groups (pre and post-test) was used to achieve the aim of the study. Setting: This study was conducted at administrative building of Benha university hospitals. Sample:  A convenience sample of 100 menopausal women divided into two equal groups (50 study groups and 50 control groups) was selected from the above mentioned settings. Tools for data collection: Data were collected by using four tools. I:  Structured interview questionnaire to assess socio-demographic and clinical characteristics. II: Overall menopausal symptoms scale. III: Beck depression inventory scale and IV: Marital Satisfaction Scale. Results: There was a highly statistical significant reduction of all items of menopausal symptoms & the level of the severity of depressive symptoms for study group  & also marital satisfaction improved after program application among study group than preprogram. Also, there were highly statistically significant positive correlation between total menopausal symptoms and total mean score of beck depression scale, negative correlation between total marital satisfaction and total depressive symptoms and negative correlation between total marital satisfaction and total menopausal symptoms of studied menopausal women pre and post-program application. Conclusion:  The psycho education program succeed to decrease menopausal symptoms, depressive symptoms and enhance marital satisfaction among studied menopausal women. Recommendation: Stress management and assertiveness training program and social skill training program should be given for all menopausal women to relieve their psychological problems and enhance their coping patterns.