Background: Diabetic foot amputation is a treatment of diabetic foot ulcers that are one of the major complications of diabetes, have a substantial impact on the health status of the affected patients and leading cause of morbidity and mortality worldwide. Aim of study: Was to assess awareness of caregivers regarding care of patients with post diabetic foot amputation. Research design: A descriptive study design was utilized to conduct this study. Setting: This study was conducted at Surgical Outpatient Clinics of Benha University Hospital, Benha Teaching Hospital and Health Insurance Hospital in Benha City. Sample: Convenience sample of caregivers for patients with diabetic foot amputation from (40- ≥ 70 years) with post diabetic foot amputation within six months from amputation. Tools: Two tools were used I): A structured interviewing questionnaire which consists of three parts. A):Demographic characteristics of patients, caregivers and patients' health profile B): Knowledge of caregivers about post diabetic foot amputation, C): Reported practices of caregivers regarding care of patients with post diabetic foot amputation, II): Scale to measure patients' satisfaction regarding care provided by their caregivers. Results: 46.9 % of caregivers had poor total knowledge about diabetic foot amputation, 56.2% of them had unsatisfactory total practices regarding care of their patients with post diabetic foot amputation and 43.8 % of the patients had low satisfaction regarding caregivers care. Conclusion: There were positive highly statistically significant correlations between total caregivers' knowledge, total reported practices and patients' total satisfaction regarding care of caregivers for their patients with diabetic foot amputation. Recommendations: Health education program for patients with post diabetic foot amputation and their caregivers to increase knowledge and practice and prevent the recurrence of foot ulcers and amputations.