Background: Leg crossing and hand griping techniques appear to have an immediate beneficial effect on decreasing vasovagal symptoms. Aim of this study: Was to evaluate the effect of leg crossing and hand griping techniques on reducing vasovagal symptoms associated with vein puncture in pediatric patients. Research design: A quasi experimental design was utilized in this study. Setting: This study was conducted at emergency department and inpatient pediatric department at both Benha Teaching Hospital and Benha University Hospital. Sample: A purposive sample of children (90) was selected. A simple random sample was used to assign the children into three equal groups according to type of intervention: Leg crossing group, Hand gripping group and control group. Tools of data collection: Three tools were used   I): A structured interviewing questionnaire to assess characteristics of studied children, Their medical data, Physiological measurements and assessment of common vasovagal signs and symptoms associated with vein puncture pre and post intervention), II): Children's Fear Scale and III): Children's satisfaction questionnaire sheet. Results: There were highly significant differences between groups of the study in relation to total vasovagal signs and symptoms associated with vein puncture and fear assessment in groups of the study pre and post technique implementation (p=<0.01). Children in the study groups were satisfied with the implemented techniques for its effect on reducing vasovagal symptoms associated with vein puncture. Conclusion: Leg crossing and handgrip techniques were associated with decrease in vasovagal symptoms of children undergoing vein puncture and experienced fewer numbers of vasovagal symptoms as compared to children in control group. Children in study groups were satisfied with the implemented techniques for its effect on reducing vasovagal symptoms associated with vein puncture. Recommendations: Leg crossing and hand griping techniques can be integrated as a part of routine daily care for children who had a past history of vasovagal symptoms associated with vein puncture.