Background: Family caregivers of patient with schizophrenia face many problems related to caregiving as, stress, anxiety and a high level of expressed emotion, the permanent negative expressed emotion of caregiving are likely to generate relapse and increase rehospitalization the schizophrenia patient. Aim of study: This study aimed to evaluate the effect of family caregiver expressed emotion control program on relapse among patients with schizophrenia. Study design: A quasi-experimental design was utilized to conduct this study. Setting: This study was conducted at Psychiatric Mental Health Hospital in Benha City, Qalyubiya Government. The hospital is affiliated to General Secretariat of Mental Health. Sample: Convenience subject of 40 family caregivers were chosen for conducting this study. Tools of Data collection: Three tools were used, I: Socio-demographic questionnaire for patients with schizophrenia and family caregivers. II:  A caregivers' knowledge questionnaire about the schizophrenia and relapse and III:  Expressed emotions scale. Results: There was highly statistically significant correlation between total patterns of expressed emotion and total knowledge during pre/ post program implementation at (P< 0.001). Conclusion: Family caregivers of patient with schizophrenia had high levels of expressed emotion, which decreased after implementation of the family caregiver expressed emotion control program. Recommendations: Designing a systematically continuous family intervention programs in psychiatric hospitals to provide proper information and psychological support that help the family caregivers to handle the difficult thoughts and emotions, reduce negative expressed emotion and reduce relapse of patients.