Back ground: Occupational health deals with all aspects of health and safety in the workplace. Safety measures are used to protect the face, eyes, ears, head, the respiratory system, the legs and other parts of the body. Aim of study: Was to evaluate the effect of safety measures and first aid practices among   the oil and soap workers. Design: A quasi-experimental design was used in carrying out this study. Setting: The study was conducted at the Oil and Soap Company at Kafr El Zayat District in Al- Gharbia Governorate. Sample: 250 workers were chosen randomly. Tools of data collection: Two tools were used: I) An Structured questionnaire comprised three parts. 1) Socio demographic characteristics of oil and soap workers. 2) Medical history of workers. 3). Knowledge about occupational health hazards pre and post program and II) An observational checklist comprised three parts. 1) Using of personal protective equipment. 2) First aid procedures pre and post program. 3) The environmental condition pre and post program. Results: There were significant relations between the studied workers' total knowledge score and their age 25 0.05) pre program. While there were no significant relations between the studied workers' total practice score and sex, and residence, sex, social status, monthly income, daily working, and years of experience post program. Conclusion: The program succeeded to improve workers knowledge and their practices. Recommendation: Develop intervention programs for workers at oil and soap companies and provide Health education program to enhance first aid and safety measures among the workers companies.