Background: As the efficacy of cancer treatments has improved and the life span for cancer patients has extended, interest in patients' quality of life has increased. Assessing patients' quality of life continues to gain importance as it impacts numerous facets of oncology. Aim of study: Was to assess the impact of psychological problems and spiritual wellbeing on quality of life among hospitalized cancer patients. Research design: A descriptive research design was utilized to conduct this study. Setting: This study was conducted at clinical oncology department at Nasser Institute Subjects: A convenient sample of 100 patients with cancer. Tools for data collection: Data were collected by using the following tools: I: Socio- demographic and clinical data questionnaire: to elicit data about patient characteristics and clinical data. II:  Spiritual Well-being Scale (SWBS)to assess spiritual well-being.  III: Simple Quality of Life Scale (FSQOLS) to assess quality of life among patients with cancer and IV: Depression, Anxiety and Stress Scale designed to measure the emotional states of depression, anxiety and stress. Results: More than half of the studied sample has poor quality of life among illness, while one tenth of them have good quality of life. Revealed that less than half of the studied sample are suffering from severe depression ,more than three quarter of them have extremely sever anxiety and more than two thirds of them have moderate stress. Conclusion: There was significant positive correlation between spiritual wellbeing and quality of life and there was negative correlation between spiritual wellbeing and stress. Recommendations: Conducting psycho-educational program for improving the psychological status of cancer patients of all types. Coordinate between oncology center and the Department of Psychiatry in the hospital for give treatment to reduce anxiety level