Background: Developing psycho- educational nursing program has impact on the quality of life among bladder cancer patients with urinary diversion Aim of study: Was to determine the effect of psycho-educational nursing program for enhancement the quality of life among bladder cancer patients with urinary diversion. Research design: A quasi experimental design (pre and post - test) was used to achieve the aim of the study. Setting: This study was conducted at the Surgical Ward and Outpatient Clinics in National Cancer Institute, Cairo University. Sample: Purposive sample of 40 patients with urinary diversion from National Cancer Institute were selected from surgical ward. Tools of data collection: Two main tools were used, I: Structured interviewing questionnaire consisting of: Socio-demographic data and clinical data for patients. II: Pre-post assessment consisting of knowledge assessment questionnaire, Hamilton Anxiety Rating Scale and quality of life questionnaires. Results: There was a highly statistically significant improvement regarding to the total mean scores of Knowledge, quality of life and anxiety at post comparing to pre- program implementation. Conclusion: The findings of the study confirmed the effectiveness of psycho-educational nursing program for enhancement the quality of life among bladder cancer patients with urinary diversion. Recommendations: Providing patient with urinary diversion with needed support as well as an educational program will help them throughout respond in healthy to the urinary diversion.