Background: Osteoporosis is a major public health problem worldwide especially among menopausal women in the world, which can be prevented or its onset can be delayed through health education and lifestyle changes.  Aim of study: Was to evaluate the effect of application of PRECEDE-PROCEED model (PPM) based education for prevention of osteoporosis risks among perimenopausal women. Design: A quasi-experimental design was used to achieve the aim of the study. Setting: This study was conducted at the Administrative building of Benha University hospital (administrator employee). Sample: A purposive sample was carried out in the study according inclusion criteria. The sample consists of 109 perimenopausal women were divided randomly into two groups (control group compromising 54 women and study group compromising 55 women). Tools: Two main tools were used; Self-administered questionnaire and Construction of Precede-Proceed model.  Results: There was a highly statistically significant difference was observed in all construction of Precede-Proceed model of the study group compared with the control group after application of PRECEDE - PROCEED model (p < .001). Conclusion: Application of PRECEDE-PROCEED model was effective in prevention of perimenopausal women's predisposing factors of osteoporosis, healthy practices and activities, reinforcing factors, enabling factors which supported the present study hypothesis. Recommendations: It is crucial to conduct an extensive future studies with larger sample probability sizes of perimenopausal women to enhance the accuracy of the findings, Also application of  PRECEDE-PROCEED Model Based Education program among perimenopausal women in health system to increase the level of awareness towards osteoporosis and its prevention.