Background: Coping affects self-regulation of emotions, cognitions, behaviors, and motivational orientation. Aims of study: Was to assess maternal coping with hospitalization of neonates at Intensive Care Units.  Research design: A descriptive research design was utilized to conduct the study. Setting: this study was conducted at Neonatal Intensive Care Unit at ELShohada Hospital in Menoufia and Benha University Hospital. Sample: A convenience sampling of 225 mothers^' of hospitalized at neonatal intensive care unit was selected. Tools: Four tools were used: Tool I: A structured interviewing questionnaire for mothers characteristics and their neonates. Tool II: Beck Depression Scale. Tool III: Spielberger Anxiety Scale. Tool IV Coping Process Likert Scale. Results: More than half of studied mother had poor coping mechanism, mothers was suffering from severe level of anxiety and mild depression. Conclusion: Mothers of hospitalized neonate had severe level of anxiety, mild depression. Most common coping mechanisms were turning to religion, wishful thinking and exercise of restrain. The least commonly used process was denial. Recommendations: In-service educational program must be designed for nurses about mothers coping with hospitalization of neonates and nursing strategies that can enhance and facilitate their coping