Background: Breast cancer is one of the most serious diseases affecting physical, psychological and social health of women. Aim: This study aimed to investigate the effectiveness of psycho-educational nursing program on body image, self-esteem and quality of sexual life among women with breast cancer.Research design: A quasi-experimental design one group was utilized in this study. Setting: The study was conducted at the oncology department of Benha Health Insurance Hospital in Benha City, Qaluobia Governorate. Sample: A purposive sample was constituted the study subjects; the sample size was 40 subjects with breast cancer, which carry out (pre/post). Tools of data collection: Four tools used (1): A structuredinterviewing questionnaire consisting of two parts to assess socio-demographic and clinical characteristics of women with breast cancer. (2): Hopwood Body Image Scale. (3): Rosenberge Self-esteem Scale. (4): Modified WHO Quality of Sexual Life Scale. Results: There were positive highly statistical significant correlations between quality of sexual life among the studied women with breast cancer, their self- esteem and body image in pre / post program implementation. Conclusion: The psycho-educational intervention had a positive effect on improving body image, self-esteem and quality of sexual life among women with breast cancer. Recommendations: Counseling intervention program on coping strategy among women with breast cancer to improve body image, self-esteem and quality of sexual life.