Background: Dissociative disorder is a mental disorder that  characterized  by a disruption in the normal integration of consciousness, memory, emotion, perception, identity, body representation, motor control, and behavior. Aim of study: Was to assess dissociative disorder and its relation to stress among adolescents. Research design: A descriptive study design was utilized. Sample: A convenience sample composed of 572 students of first grade. Setting: The study was carried out at Faculty of Nursing at Benha University in Benha City. Tools of data collection: Three tools were used, I: A structured Interview Questionnaire about the socio-demographic data of studied adolescents. II: Dissociative Experience (DES) to assess the dissociative disorder and III Stress scale to assess stress.  Results:  Majority of studied sample have low level of total dissociative disorder and half of the studied students have moderate level of total stress. Conclusion:  There is a significant positive correlation between total students dissociative disorder and their totals stress disorder. Recommendations: Psycho-educational program focused on the psychological, physiological and social needs of adolescents. Further studies for larger Sample should be done to generalized results.