Background: Workplace violence is a serious phenomenon involving the health care settings, and presents challenges to management. The consequences can be devastating, since it affects nurses' morale, decreases job satisfaction and altered job performance. The study aimed to assess the effectiveness of workplace violence management training program on job satisfaction among staff nurses. Design: A quasi-experimental design was used. Setting: The study was conductedat Benha University Hospital. Sample: Included 158 staff nurses. Tools of data collection: Three tools were used for data collection: (1) Work place Violence Knowledge Questionnaire, (2) Staff Nurses' Performance Observational Checklist and (3) Job Satisfaction Questionnaire. Results: There was a statistically significant improvement in staff nurses knowledge and performance on their activities for prevention and managing violence against staff nurses after program intervention. Also, there was a statistically significant improvement on job satisfaction among staff nurses after program implementation. Conclusion: Implementation of training program for workplace violence management was associated with significant improvement in staff nurses' knowledge, performance about managing and preventing workplace violence against nurses and increase job satisfaction among nurses. Recommendation: Work place policies and procedures are needed that focus on security of the environment, reporting and surveillance, and education for all employees and managers on how to prevent and managing violence.