Background: Perimenopause represents a critical life stage encompassing a range of physiological and psychosocial changes that require a healthy lifestyle to promote health and functioning. Aim: The study aimed to investigate the effect of an educational program on lifestyle of perimenopausal women utilizing PRECEDE-PROCEED model. Design: Quasi-experimental (study-control / time series) study was utilized. Setting: Administrative building of Benha university hospitals. Sample: A purposive sample of (109 women) was selected according to inclusion and exclusion criteria. The sample consisted of two groups (study group comprised (55) perimenopausal women who received the program and control group comprised (54) perimenopausal women who didn't not receive the program).Tools of data collection: A structured interviewing questionnaire sheet, and health-promoting lifestyle profile. Results: After three and six months of program application, the mean scores of predisposing factors, reinforcing factors, enabling factors and health promoting lifestyle of the study group were significantly higher than the scores in the control group (P < 0.001).Conclusion: PRECEDE - PROCEED model provided an excellent framework for health intervention programs and improved the understanding of the relationship among health-promoting lifestyle, educational and ecological assessment phase structures and demographic factors. Recommendation: Implementing an educational intervention based on PRECEDE - PROCEED model on women's lifestyle at different stages of life and settings especially workplaces with high female density.