Background: Managerial innovation is necessary at the workplace to enhance head nurse's professional competency so head nurses need to adopt with clear and attainable system for managerial innovation in health care sector. The study aimed to assess the effect of managerial innovation educational program for head nurses on their professional competency. Design: A quasi- experimental design was utilized. Setting: The study was conducted at Benha University Hospitals in all medical and surgical buildings. Subjects: Consisted of 55 head nurses. Tools of data collection: Three tools were used in the present study for data collection, innovation knowledge questionnaire, managerial innovation skills questionnaire and professional competency questionnaire, Results: Minority of head nurses (12.7%) had good level of knowledge at preprogram phase while increased to more than two thirds (81.8%&70.9%) at post program and follow up study phases. The most (85.5%& 80%) of head nurses had high level on managerial innovation skills at post program and follow up phases respectively as compared to preprogram phase (14.5%). Most (81.8%& 70.9%) of head nurses had good professional competency at post program and follow up, respectively. Conclusion: There was a highly positive statistically significant correlation between head nurses' managerial innovation knowledge, skills, and level of professional competency at post and follow up program phases. Recommendations: Hospital management can organize educational programs for refreshing and increasing knowledge and skills about nurses' innovation as well as emphasizing managerial innovation skills of head nurses.