Background: Patients aggression acts are a part of the average working day for psychiatric nurses. Identifying the risks in practice & adapt knowledge are the first steps in developing safe work practices and enhance positive attitude toward patient aggression. Aim: This study aimed to evaluate the effect of psycho-educational program for psychiatric nurses to protect themselves and others from the incidence of acute psychiatric inpatients aggression. Research design:A quasi-experimental design two groups control and study groups was utilized in this study. Setting: the study was conducted at the Psychiatric Mental Health Hospital in Banha City. Sample: A purposive sample of 100 nurses was constituted the study subjects, which divided into two groups study and control group (pre/post/ test) 50 nurses for each group. Tools of data collection: Five tools were used for data collection, (1): A structuredinterviewing questionnaire consisting of two parts: to assess Socio-demographic data for nurses, (2): Attitudes towards aggression scale, (3): Knowledge questionnaire about aggression, (4): Skills questionnaire about dealing with patient aggression and (5): The Perception of Prevalence of Aggression Scale. Results: The majority of study sample had positive attitude, adequate knowledge, competent skills and highly level of perception of aggression post program compared with pre educational program. Conclusion:There is positive significant correlation between skills, attitude and knowledge of study group at post the educational program. Recommendation: Aggression-management training programs should be given to all psychiatric nurses to enhance their confidence, knowledge and skill on management of patients aggression.