Back ground: Perioperative hypothermia is a significant problem for surgical patients globally, and is associated with a range of adverse effects, including inflammation, prolonged surgical wound healing, increased wound infection rates, and prolonged hospital stay. Aim of the study: To evaluate the effect of educational program regarding perioperative hypothermia on nurses` performance and abdominal surgery patients` outcomes. A quasi experimental research design was utilized to conduct the aim of the study. Sampling: A convenient sample of all available nurses (85 nurses) who are working in operating room and general surgical ward were included in the study. A fifty purposive sample of patients who were admitted to general surgical ward and operating room up to six months included in the study. Setting: The current study was conducted in operating room and general surgical ward (male & female) at Benha University hospital. Tools for data collection: Data were obtained through three tools; Self-administered questionnaire for nurses, Nurses practice observational checklist and patients` outcomes tool. Result: The study showed that a highly statistical significant improvement in the total mean knowledge and practice scores of studied nurses immediately post and after one month of program implementation as compared to preprogram implementation. Also, there was a highly statistically significant improvement in nurses` total practice and wound assessment score post program implementation with statistical significant between nurses` total practice and length of hospital stay immediately post of program implementation. Conclusion; there was positive correlation between nurses` total knowledge and practices regard perioperative hypothermia through program phases, which indicated that improved patients' outcome. The study recommended that, there is needed forreplication of the current study on larger probability sample is recommended to achieve generalization of the results. Also, there is needed to duplicate the study to determine the effect of educational program on postoperative patient outcome.