Background: Once preeclampsia is diagnosed, evidence-based interventions may reduce the risk or severity of maternal and infant health outcomes of preeclampsia. Aim of the study: Was to assess nurses knowledge and practices regarding the use of evidence-based for pregnant women with pre-eclampsia. Design: A descriptive study design was utilized to achieve the aim of the study. Setting: The present study was conducted at obstetrical and gynecological department at Benha University Hospital. Sampling: A convenient sample. Tools: Three tools were used for data collection:A self-administered questionnaire, Observational checklist and Modified Likert scale. Result: There were more than one third of studied nurses(41.7%) had average level of total knowledge about EBP and preeclampsia, less than two third of studied nurses (65%) had satisfactory level of total practices regarding preeclampsia and more than half of studied nurses (53.4) had high level of awareness about barriers. Conclusion: There was statistical significance positive correlation between total practices, total knowledge about evidence based practices and total knowledge of preeclampsia. Recommendation: Improving nurse's awareness regarding EBP through involving them in educational programs to encourage them to utilized EBP into patient daily care.