Back ground: Physical restraint is used to prevent therapy discontinuation, patients` falls and injuries, and to protect patients from removing tubes, drains, and medical equipment connected to their body. Aim of the study: To evaluate the effectiveness of an educational program on critical care nurses` performance and patients outcomes regarding physical restraints. Research design: A quasi experimental research design was utilized to conduct this study. Sample: A convenient sample consisted of 60 critical care nursing staff working in intensive care unit who apply physical restraint to critical ill patients and A purposive sample includes 72 patients were admitted to intensive care unit up to six month. Tools of data collection: Data were obtained through two tools; Self-administered questionnaire for nurses, Nurses' practice observational checklist tool and clinical outcomes tool for patients. Results: There was highly statistically significant differences in the total mean knowledge and practice scores of studied nurses immediately post and after one month of program implementation as compared to preprogram implementation. Also, there was statistically significant correlation between nurses` total knowledge and patient outcome with statistically significant between nurses` total practice and patient outcomes immediately post and after one month. Conclusion: There was a highly statistical significant improvement of studied nurses` knowledge and practice through program phases, which indicated that improved patients' outcome. Recommendations: Orientation programs are needed for newly graduated nurses to improve their practice and knowledge and to maintain effective nursing care for patient under physical restraint.