Camel is an ancient species reared for different purposes since long time ago. In spite of cruel environmental conditions exposed to camels, it has the ability to sustain. Whilst, hemoprotozoans are diseases significantly upset camel's health induced economic loss. Theileria is a vector borne hemoparasites resulted in fatal financial losses. However, current consideration planned for investigation of hemato-biochemical and histopathological changes induced in camels during haemoparasitism. One hundred camels were under study from the slaughter houses in Aswan Province. During October 2019 to September 2020, blood samples were collected from jugular veins for complete hematological picture and biochemical assays. Moreover, samples from lymph nodes and liver were taken and fixed in 10 % neutral buffered formalin for further pathological examinations. From the survey results, our study investigated that about 15 % of camels were positive for Theileria infection. Generally Thieleria spp. was represented the highest incidence of infection in autumn (8%), and the lowest incidence of infection through different seasons was represented in spring only (1%) Thieleria spp. Hematologically, Theileria was significantly decreased red blood cell (RBCs) count, hemoglobin (Hb.) concentration and packed cell volume (PCV) in comparison with non-infected camels. Biochemical results revealed significant elevation in serum aspartate aminotransferase (AST) and urea in Theileria infected camels when compared with non-infected camels. Histopathologically, Theileria infected camel's revealed necrosis of the lymphoid follicles and vacuolar degeneration in the hepatocytes. From the previous findings, it could be concluded that Theileriosis manifested with hemato-biochemical alterations, additionally histological deteriorations among slaughtered camels.