The present study was carried out during 2019 and 2020 seasons to study the effect of yeast and landamine_Zn spraying as well as girdling and leaf defoliation on yield and berry quality of Early Sweet grapes. The experimental set up in a randomized complete block design, where, the study included seven treatments with three replications one vine each. Yield/vine and cluster weight were significantly increased due to spray yeast or landamine_Zn as well as girdling or leaf defoliation compared to untreated one (control). Spraying 4 g/L landamine_Zn was very effective in increasing yield and cluster weight than other treatments. Moreover, all studied treatments significantly improved the berry quality in terms of increasing berry weight, reducing sugar total soluble solids and decreasing berry firmness and total acidity compared to untreated ones. No significant differences which obtained due to spray landamine_Zn at 2 or 4 cm³/L, as well as yeast, girdling or leaf defoliation. It could be concluded that spraying 2 to 4 cm³/L landamine_Zn to get high yield with good cluster and berry quality. In addition, to avoid damages arising from girdling and leaf defoliation of Early Sweet grapes.