The large amount of uncertainties in liquefaction-induced lateral spreading particularly leads to pile damage after many earthquakes. This paper presents a simplified safety analysis method of the single piles subjected to lateral spread in three layered soils. With the suggested method the analyst can get a quick estimate of the pile safety using few simulations of the pile-soil structural model. The method integrates a limit equilibrium-based finite element model with the response surface method as well as the first or the second order reliability method (FORM/SORM). In the finite element model, the assumptions of limit equilibrium method are simply applied. The soil is represented by 3D solid elastoplastic (Drucker-Prager failure criterion) while the pile is represented by an elastic 3D beam element. The simplified procedure not only estimates the safety but also determines the most sensitive basic pile and soil parameters affecting the response. Both serviceability and ultimate limit states are applicable. The accuracy of the proposed analytical method is evaluated against the Monte Carlo Simulation Method. At the beginning, two simple examples are used to verify, validate and further illustrate the method. After that, a more complex example is used to substantiate the superiority of the method. The effect of numerous uncertainties associated with the system is taken into account.