The point of the present work was intended to think about the impacts of Niacin, Hedera helix  on the asthma. Related parameters after enlistment of asthma for 28 days and in Balb/c mice, notwithstanding research a plausibility of accomplishing a joined advantage of niacin and Hedera helix treatment on cytokines, total protein and the histological examination of lung. The white and differential blood count in BAL (Eosinophil infiltration) is the Asthma marker.  The activity level of GSH in the tissue of lung of mice recorded significant increases (p ≤ 0.05) and that the level of GSH was significantly decreased in asthma group compared to control group.  The group which was treated by a combination increased by 39.9% compared to the asthma group. The total thiol in lung tissue of mice recorded significant increases in level of T-thiol in all the treated groups compared to asthma group and the group which was treated by niacin, Hedera helix and the group of combination recorded 60.8%, 60.6%, 68.3%; respectively, while the asthma group recorded a significant decreased. There were significant decreases (p ≤ 0.05) in the level of SOD activity in the tissue of mice in niacin, Hedera and niacin –Hedera combination groups as compared to control group, while recording increases of 121.3%, 54.7% and 130.7% when compared with asthma treated group, the results showed significant decreases in asthma group the data showed the difference between asthma group and niacin group by 0.001, while with Hedera group 0.602 and combination group 0.001 as compared to asthma group. There was huge increment in TNF-α in asthma group while, in other treated groups there were huge diminished contrasted with asthma niacin, Hedera, niacin-Hedera blend 0.999, 0.920 and 0.812; respectively.