Abstract Purpose – Individual and organizational factors are an ontological comprise a firm's climate that support initiating knowledge creation process, socialization, externalization, combination, and internalization (SECI). Thus it has a significant effect on organizational knowledge creation processes. Then SECI create knowledge in the organizations in various forms that varies between tacit and explicit, private and public knowledge; individual and organization knowledge that build organizational knowledge "epistemological" in the organization. The purpose of this study is to investigate the effect of ontological factors on organizational knowledge creation processes (OKCP). Methodology ــUsing survey approach, the data collected from 90 respondents selected from various pharmaceutical organizations, these organizations divided into three sectors according to capital size. So the research community studied three sectors of pharmaceutical organizations; big, medium, and small sector; that is to make comparisons between these sectors to define the variance between factors affect OKCP, and the validation of OKCP in different sectors on the other hand. Findings – This study found that individual and organizational factors "ontological" play a critical role in organizational knowledge creation processes. Individual and organizational factors have a positive impact on knowledge creation processes, and the four process of organizational knowledge creation"SECI" lead to creating organizational knowledge in the organization Originality– This study not only contributes to knowledge creation processes by identifying a key antecedent of knowledge creation four modes but also is of importance to knowledge creation literature by demonstrating the proper effect of individual and organizational factors– as an ontological- on the processes of creating organizational knowledge. Keywords Organizational Knowledge creation process (OKCP), individual factors; user involvement, knowledge cognition, and organizational factors.