The present study investigates the antimicrobial effects of the total methanolic extracts and different fractions of Gelditsia triacanthos fruits and Gelditsia caspica leaves against G +ve and G –ve bacteria and fungi. Methanolic extract of G. caspica had prominent antifungal activity against A. niger about 88% of ketoconazole potency. Butanol extract of G. caspica had relative antimicrobial activity approximately 64% of Gentamicin standard against S. typhimurium. Butanol extract of G. triacanthos had moderate antifungal activity against A. niger approximately 73% of ketoconazole potency. Petroleum ether extract of G. triacanthos achieved antifungal activity approximately 75% of ketoconazole potency against C. Albicans whereas it had relative antimicrobial activity approximately 70% of Gentamicin standard against S. typhimurium. While anti-inflammatory properties of the total methanolic extracts and different fractions of Gelditsia triacanthos fruits and Gelditsia caspica leaves revealed that the ethyl acetate fraction of G. caspica has anti-inflammatory activity about 29% of the standard diclofenac, whereas, different fractions of G. caspica were found to be less effective as anti-inflammatory. Finally total methanolic extracts and different fractions of Gelditsia triacanthos fruits were evaluated for their anti-tuberculosis activity and showed that butanol extract of G. triacanthos achieved anti-mycobacterial potency about 0.006% of the standard isoniazid.