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139026

Validated Spectrophotometric method for analysis of Dipyridamole and Lamivudine using eosin Y

Article

Last updated: 04 Jan 2025

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Subjects

-

Tags

Analytical chemistry
Pharmaceutical and medicinal chemistry

Abstract

Validated, accurate, simple and reliable spectrophotometric method was described for the assay of dipyridamole and lamivudine in their different dosage forms. The suggested method depended on a binary reddish orange coloured complexformation between eosin Y and each one of the two analytes in presence of carboxy methyl cellulose and aqueous buffered medium for dipyridamole and lamivudine, respectively at pH 3.7. The coloured binary complexes exhibited maximum absorbance at 554.0 nm for dipyridamole and lamivudine. The absorbance concentration graphs were linear over ranges of (1.0-10.0 μg/mL) and (2.0-20.0 μg/mL), with lower detection limits of 0.27 μg/mL and 0.46 μg/mL and lower quantitation limits of 0.82 μg/mL and 1.40 μg/mL for dipyridamole and lamivudine, respectively. The developed method was applicable to the assay of dipyridamole and lamivudine in their different dosage forms, and the obtained results were in acceptable agreement with all those provided by reference methods. The present method is appropriate for the assay of the two drugs on account of its cost effectiveness, simplicity and rapidity

DOI

10.21608/aijpms.2021.52761.1016

Keywords

Spectrophotometric, dipyridamole, Lamivudine, eosin Y, dosage forms

Authors

First Name

Sona

Last Name

Barghash

MiddleName

Soliman

Affiliation

Pharmaceutical Analytical Chemistry ,Faculty of Pharmacy,Al-Azhar University ,Cairo,Egypt

Email

suna_soliman@yahoo.com

City

Mansoura

Orcid

-

First Name

Sawsan

Last Name

Abd El-Razeq

MiddleName

-

Affiliation

Analytical Chemistry,Faculty of Pharmacy,Al-Azhar University,Cairo,Egypt

Email

razeqhegab@yahoo.com

City

-

Orcid

0000-0003-0996-o676

First Name

Mohamed

Last Name

El -Awady

MiddleName

-

Affiliation

Analytical Chemistry,Faculty of Pharmacy,Mansoura University,Mansoura, Egypt

Email

mohamedelawady2@yahoo.com

City

-

Orcid

-

First Name

Fathalla

Last Name

Belal

MiddleName

-

Affiliation

Analytical Chemistry,Faculty of Pharmacy,Mansoura University,Mansoura,Egypt

Email

ffbelal@yahoo.com

City

-

Orcid

-

Volume

1

Article Issue

1

Related Issue

20376

Issue Date

2021-01-01

Receive Date

2020-12-12

Publish Date

2021-01-01

Page Start

87

Page End

96

Print ISSN

2735-4598

Online ISSN

2735-4601

Article File

AIJPMS_Volume 1_Issue 1_Pages 87-96.pdf

PDF . 486.7kB

Link

https://aijpms.journals.ekb.eg/article_139026.html

Detail API

https://aijpms.journals.ekb.eg/service?article_code=139026

Order

9

Type

Original research articles

Type Code

1,562

Publication Type

Journal

Publication Title

Azhar International Journal of Pharmaceutical and Medical Sciences

Publication Link

https://aijpms.journals.ekb.eg/

MainTitle

Validated Spectrophotometric method for analysis of Dipyridamole and Lamivudine using eosin Y

Details

Type

Article

Created At

23 Jan 2023