Smart marketing has a large number of methods such as websites, search engines, social media sites, mobile apps, videos, etc. which play a vital role in enhancing the relationship between travel agency and tourists. Therefore, This study aims to identify the Smart Marketing Methods and, and explore the opportunities and challenges of using Smart Marketing Methods in Domestic Tourism in Egypt. Accordingly, it adapted the descriptive the descriptive methodology and used a mixed approach in collecting data quantitatively and qualitatively. (a) The quantitative approach is used by employing questionnaire to gather the primary data from domestic tourists in Egypt. (b) As for the qualitative method, it is represented in semi-structured interviews with Top Ten Travel Agencies representatives in Egypt. The main results of study demonstrated that there are many advantages of using smart marketing methods in Domestic Tourism in Egypt; however, there are some obstacles that have clear impacts upon them. The study recommends that Travel Agencies and Tourism Associations in Egypt should apply formal platform to promote Domestic Tourism and improve their marketing strategy to take advantages of using Smart marketing methods in Tourism.