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262293

Evolving phenotype of systemic lupus erythematosus patients and correlation with antibody against c1q: A review article

Article

Last updated: 27 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Infection and immunity.
Internal Medicine.
Musculoskeletal disorders.

Abstract

Background: Systemic lupus erythematosus (SLE) is a persistent illness that results in inflammation of connective tissues, including cartilage and the lining of blood vessels, which give structures throughout the body their flexibility and strength. A multi-system autoimmune illness, SLE affects several organ systems. There are several phenotypes of the illness, and clinical symptoms in individuals may range from modest mucocutaneous signs to severe central nervous system involvement affecting multiple organs. SLE is an illness that develops along many immune-pathogenic pathways.
Aim: To explore various phenotypes of SLE and possible role of anti-C1q antibodies in SLE  
Conclusion: Anti-C1q antibodies were strongly associated with lupus disease activity in SLE patients, suggesting that it may be a reliable, sensitive, and non-invasive serological marker for SLE patients with active SLE disease.

DOI

10.21608/svuijm.2022.158094.1392

Keywords

Anti-C1q, Systemic lupus erythematosus, Lupus nephritis, complement, Proteinuria

Authors

First Name

Khalid Abd El Monem

Last Name

Zaki

MiddleName

-

Affiliation

Physical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, Al-Azhar University (Cairo Branch), Cairo, Egypt.

Email

khaled_zaky@hotmail.com

City

Cairo

Orcid

-

First Name

Mohamed Ismail

Last Name

Abdelkareem

MiddleName

-

Affiliation

Physical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, Al-Azhar University (Assiut Branch), Assiut, Egypt.

Email

mohamedkareem2000@yahoo.com

City

-

Orcid

-

First Name

Wael Abd El Mohsen

Last Name

Abady

MiddleName

-

Affiliation

Physical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, South Valley University, Qena, Egypt.

Email

waelrheuma@yahoo.com

City

Qena

Orcid

-

First Name

Asmaa

Last Name

Nafady

MiddleName

-

Affiliation

Clinical Pathology Department, Faculty of Medicine, South Valley University, Qena, Egypt.

Email

asmaa.nafady@med.svu.edu.eg

City

-

Orcid

-

First Name

Zeinab Abd El Razek

Last Name

El Tieb

MiddleName

-

Affiliation

Physical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, South Valley University, Qena, Egypt.

Email

seseomar@yahoo.com

City

Qena

Orcid

-

Volume

6

Article Issue

1

Related Issue

35538

Issue Date

2023-01-01

Receive Date

2022-08-29

Publish Date

2023-01-01

Page Start

291

Page End

301

Print ISSN

2735-427X

Online ISSN

2636-3402

Article File

SVUIJM_Volume 6_Issue 1_Pages 291-301.pdf

PDF . 201.3kB

Link

https://svuijm.journals.ekb.eg/article_262293.html

Detail API

https://svuijm.journals.ekb.eg/service?article_code=262293

Order

31

Type

Reviews Articles.

Type Code

1,521

Publication Type

Journal

Publication Title

SVU-International Journal of Medical Sciences

Publication Link

https://svuijm.journals.ekb.eg/

MainTitle

Evolving phenotype of systemic lupus erythematosus patients and correlation with antibody against c1q: A review article

Details

Type

Article

Created At

23 Jan 2023