Background: H.pylori is a Gram-negative bacterium known to be associated with peptic ulcer disease, gastric cancer, gastric lymphoma. Recently it was detected in mucosa of patients with CRS, but relation with bilateral nasal polyposis has not been demonstrated yet.
Objectives: H. pyloriis a pathogen that lives in the gastrointestinal tract (GIT) and has extragastric manifestations. Nasal polypi may be one of these manifestations. This study aims to detect the relation between H.pylori and bilateral nasal polypi.
 Patients and methods: This study includes 80 cases of nasal polypi, 40 of them were de novo bilateral nasal polypi and 40 were recurrent nasal polypi, biopsies of nasal polypi were taken under sterile conditions and stained with Giemsa stain and Hematoxylin and eosin(H&E) stain. Stool analysis was done to detect presence of H.pylori using rapid urease test.
Results: Both groups are age and sex matched. Nasal polyp biopsies showed positive results in 10 % of denovo group and 15 % of recurrent group with p value 0.449 which is not statistically significant. Stool antigen test showed positive results in 52.5 % of denovo group and 60 % of recurrent group with p value 0.449 which is not statistically significant.
Conclusion: There is no statistically significant relation between H.pylori and the pathogenesis of bilateral nasal polypi, further studies with large number of patients is recommended.