Background: Around the world, non-alcoholic fatty liver disease is the main cause of liver diseases. A substantial relationship between NAFLD and H.pylori infection has been discovered recently. Objectives: We aimed to explore the relationship between H.pylori infection and NAFLD in Egyptians. Patients and methods: A case-control study involved 200 patients who underwent Oesophagogastroduodenoscopy. We divided Participants into 2 groups: Group A: contained 100 patients with confirmed H Pylori infection, Group B: contained 100 patients without H.Pylori infection. We diagnosed Fatty liver by ultrasonography. Results: Our study results showed that prevalence of non-alcoholic fatty liver disease (NAFLD) was similar in patients with H.pylori infection in comparison to control group (16% Vs 12% in GroupA and B, respectively). We found that the prevalence of dyslipidemia was higher in patients with H.pylori infection in comparison to control group. Conclusion: There is no significant relationship between H.pylori infection and non-alcoholic fatty liver disease (NAFLD). Dyslipidemia was higher in patients with H.pylori infection than in healthy persons.