Background: The liver alters exogenous and endogenous chemicals, foreign molecules and hormones to make them less toxic or less biologically active. The Fluoride causes impairment of liver function, causing decrease in metabolic activities, increased serum indices of liver function tests and inhibits certain antioxidant enzymes and molecules.
Objectives: To evaluate the effect of Sodium Fluoride (NaF) on the liver of male albino rats and the role of Vitamin C.
Animals and methods: This study was carried out on 30 adult male albino rats. The rats were randomly categorized into 3 equal groups of animals, 10 animals for each. Animals were given normal saline in Group (A), sodium Fluoride in Group (B),sodium Fluoride  and Vitamin C in Group (C).
Results: Sodium Fluoride caused toxic effects on the liver. In the form of loss of normal pattern, dilated congested thick walled portal vein that contained hemolysed blood cells. Also there was mild dilatation in the thick walled hepatic artery and in the bile duct. After treatment with Vitamin C, there was an improvement in the picture of the liver.
Conclusion: Vitamin C can diminish these toxic changes induced by NaF on the liver tissue.