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212147

Immunohistochemical Expression of Caspase-3 in Colorectal Carcinoma

Article

Last updated: 27 Dec 2024

Subjects

-

Tags

Disease pathology.

Abstract

Background: Apoptosis is an important factor in the development of tumors especially colorectal carcinomas (CRC). Caspase-3 is considered an ideal marker for measuring apoptosis in these tumors. Objectives: To evaluate the Caspase-3 expression and its correlation with the available clinicopathological criteria in patients with CRC. Patients and methods: Fifty cases of CRC removed by colectomy were enrolled in this study. Caspase-3 expression was evaluated by immunohistochemistry (IHC) using streptavidin-biotin-technique. Results: Caspase-3 appeared as brownish nuclear staining and was expressed in all cases of CRCs. Caspase-3 showed positive significant correlation with age (p= 0.046), histological variant (p= 0.02),and negative correlation with tumor grade (p < 0.001), depth of tumor invasion; T stage (p < 0.001) and lymph node status(p < 0.001). Conclusion: High expression of Caspase-3 in CRC patients related to favorable clinicopathological features and could be a potential independent prognostic factor. Caspase-3 may act as a tumor suppressor in CRC.

DOI

10.21608/svuijm.2022.108052.1246

Keywords

Colorectal carcinoma, apoptosis, Immunohistochemistry, Caspase-3

Authors

First Name

Sheren FM

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Pathology, Faculty of Medicine, Sohag University, Sohag, Egypt.

Email

shery.pathology@yahoo.com

City

Sohag

Orcid

-

First Name

Christeen NB

Last Name

Bernaba

MiddleName

-

Affiliation

Department of Pathology, Oncology Sohag Center, Sohag ,Egypt

Email

kristeenpeter@gmail.com

City

Sohag

Orcid

-

First Name

Eman M.S.

Last Name

Muhammad

MiddleName

-

Affiliation

Department of Pathology, Faculty of Medicine, Sohag University, Sohag, Egypt.

Email

eman_shalabi@med.sohag.edu.eg

City

-

Orcid

-

Volume

5

Article Issue

1

Related Issue

28020

Issue Date

2022-01-01

Receive Date

2021-11-26

Publish Date

2022-01-01

Page Start

240

Page End

251

Print ISSN

2735-427X

Online ISSN

2636-3402

Link

https://svuijm.journals.ekb.eg/article_212147.html

Detail API

https://svuijm.journals.ekb.eg/service?article_code=212147

Order

26

Type

Original research articles

Type Code

1,520

Publication Type

Journal

Publication Title

SVU-International Journal of Medical Sciences

Publication Link

https://svuijm.journals.ekb.eg/

MainTitle

Immunohistochemical Expression of Caspase-3 in Colorectal Carcinoma

Details

Type

Article

Created At

23 Jan 2023