Background: Indications for laparoscopic splenectomy are the same as those of open splenectomy, except for the trauma cases, where the role of laparoscopy is still debatable. More studies are needed to determine the real value of laparoscopy in massive splenomegaly. Objectives: The aim of the work is evaluation of the outcomes, safety and efficacy of laparoscopic splenectomy in non-traumatic splenic disorders. Patients and methods: This prospective study conducted on patients with hematological disorders indicated for splenectomy for one year. Results: We operated 20 patients of laparoscopic splenectomy, 70% were females, their mean of age by years were 18.9 ± 9.1. No post-operative complications the mean of operation time by hours was3.2 ± 0.7, while the mean of hospital stay was 2.3 ± 0.2 days. The total intra-operative blood loss was about 50–600 ml. Conclusion: Laparoscopic splenectomy for elective operations of the spleen is a safe method associated with a lower risk of peri-operative complications, less mortality and morbidity.