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198503

Effects of obesity-related inflammatory markers on psychosomatic manifestations of premenstrual tension syndrome: towards better therapeutic outcomes (An original article)

Article

Last updated: 27 Dec 2024

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Subjects

-

Tags

Laboratory medicine.
Neuropsychiatric diseases.
Obstetrics and Gynecology.

Abstract

Background: Obesity-induced inflammation facilitates depression and premenstrual tension syndrome. Hypoxia is a common feature of inflammation. Hypoxia inducible factors adapt cells to low oxygen tension and inflammation.
Objectives: We aimed to see how obesity, along with Amiloride, Hydrochlorothiazide, Metformin, calorie restriction, and walking exercise, affected psychosomatic characteristics of premenstrual tension syndrome, during a six-month period.
Patients and methods: A prior ethical committee approval and informed patients' consent were taken. This study was performed in Tanta University, Egypt from May 2019 to December 2019. This study aims at evaluating the effects of obesity-induced inflammatory mediators on psychosomatic effects in women having premenstrual tension syndrome. Effects of combined therapy using (Metformin, Amiloride.  Hydrochloride/ Hydrochlorthiazide,  caloric restriction, half an hour of walking exercise per day, and Vitazinc capsules) treatment was compared to the same combined therapy including Royal vitamin G treatment (instead of Vitazinc) on alleviating psychosomatic manifestations of premenstrual tension syndrome. Sixty obese women having premenstrual tension syndrome were categorized into younger age group (18-39 years) and older age (40-48 years) versus a non-obese age-matched control 
group. Body mass index in addition to serum tumour necrosis factor-α (TNF- α), hypoxia-inducible factor-1α (HIF-1α) and receptor activator of nuclear factor- kappa-Β ligand (RANKL) were assessed. Related psychosomatic manifestations of premenstrual tension syndrome (edema, anxiety, and fatigue) were also assessed.
Results: Obesity significantly increased serum TNF-α (p < 0.01), HIF-1 α (p < 0.01) and RANKL (p < 0.01). Obesity-induced biochemical effects were higher in older obese women than younger ones. Obesity significantly exaggerated the severity of investigated psychosomatic manifestations (p < 0.001). Both combined therapies (including either Vitazinc or Royal vitamin G) significantly and dramatically decreased the percentage of cases having psychosomatic manifestations (p < 0.001) that was closely related to the decreased serum biochemical parameters.
Conclusion: Combined therapy containing Royal vitamin G significantly improved serum biochemical parameters and psychosomatic manifestations better than combined therapy containing Vitazinc.

DOI

10.21608/svuijm.2021.91586.1211

Keywords

Premenstrual tension syndrome, psychosomatic manifestations, anxiety, royal vitamin G and Vitazinc

Authors

First Name

Reham A.

Last Name

Mariah

MiddleName

-

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Egypt

Email

-

City

-

Orcid

-

First Name

Samia A.

Last Name

El-Dardiry

MiddleName

-

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Egypt

Email

-

City

-

Orcid

-

First Name

Heba A.

Last Name

Mahmoud

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Medicine, Tanta University, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed M

Last Name

Mabrouk

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine, Tanta University, Egypt

Email

-

City

-

Orcid

-

First Name

Nawal A.

Last Name

El-Dardiry

MiddleName

-

Affiliation

Department of Obstetrics & Gynaecology, Faculty of Medicine, Tanta University, Egypt

Email

-

City

-

Orcid

-

First Name

Hanan Yousef

Last Name

Aly

MiddleName

-

Affiliation

Department of Neuropsychiatry, Faculty of Medicine, Sohag University, Egypt

Email

-

City

-

Orcid

-

First Name

Faten M.

Last Name

Omran

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Medicine, Sohag University, Egypt

Email

-

City

-

Orcid

-

First Name

Manal Mohamed Helmy

Last Name

Nabo

MiddleName

-

Affiliation

Division of Pediatric Cardiology, Department of Pediatrics, Hail directorate of Health, Hail, Saudi Arabia & Sohag Teaching Hospital, Sohag, Egypt.

Email

-

City

-

Orcid

-

First Name

Tamer M

Last Name

Soliman

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Sohag University, Egypt

Email

-

City

-

Orcid

-

First Name

Abdelhady Ragab

Last Name

Abdel-Gawad

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Sohag University, Egypt

Email

-

City

-

Orcid

-

First Name

Nivin

Last Name

Baiomy

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Tanta University, Egypt

Email

-

City

-

Orcid

-

First Name

Reda S

Last Name

Yousef

MiddleName

-

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Sohag University, Egypt

Email

-

City

-

Orcid

-

First Name

Nesreen Ali

Last Name

Mohammed

MiddleName

-

Affiliation

Department of Public Health and Community Medicine, Faculty of Medicine, Sohag University, Egypt

Email

-

City

-

Orcid

-

First Name

Salah Mohamed

Last Name

El Sayed

MiddleName

-

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Sohag University, Egypt & Department of Clinical Biochemistry, Taibah Faculty of Medicine, Taibah University, Saudi Arabia.

Email

salahfazara@yahoo.com

City

Sohag

Orcid

0000-0002-9975-7200

First Name

MA

Last Name

Elsemary

MiddleName

-

Affiliation

Department of Obstetrics & Gynaecology, Faculty of Medicine, Sohag University, Egypt

Email

-

City

-

Orcid

-

First Name

Hytham Mahmoud

Last Name

Abdel-Latif

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Medicine, Sohag University, Egypt

Email

-

City

-

Orcid

-

Volume

5

Article Issue

1

Related Issue

28020

Issue Date

2022-01-01

Receive Date

2021-08-19

Publish Date

2022-01-01

Page Start

11

Page End

25

Print ISSN

2735-427X

Online ISSN

2636-3402

Article File

SVUIJM_Volume 5_Issue 1_Pages 11-25.pdf

PDF . 677.5kB

Link

https://svuijm.journals.ekb.eg/article_198503.html

Detail API

https://svuijm.journals.ekb.eg/service?article_code=198503

Order

3

Type

Original research articles

Type Code

1,520

Publication Type

Journal

Publication Title

SVU-International Journal of Medical Sciences

Publication Link

https://svuijm.journals.ekb.eg/

MainTitle

Effects of obesity-related inflammatory markers on psychosomatic manifestations of premenstrual tension syndrome: towards better therapeutic outcomes (An original article)

Details

Type

Article

Created At

23 Jan 2023