Background:Excessive daytime sleepiness is defined as the incapacity to keep alert or awake during the major waking activities of the day, causing unintentional pauses of drowsiness or sleep. Chronic kidney diseasepatients commonly suffer from excessive daytime sleepiness which in turn affectstheir quality of life. Objectives: This prospective cross-sectional study was conductedto evaluate the prevalence of excessive daytime sleepiness among chronic kidney disease patients. Patients and methods: The study was carried out on one hundred patients with known chronic kidney disease who attended Aswan University hospital during the period between May 2017 and March 2020; 42.0% males and 58.0% females with a mean age of 53.9 ± 16.97 years. We evaluated day time sleepiness among those patients using Epworth Sleepiness Scale (ESS); the standardized score for the assessment of daytime sleepiness. Results: We found that 56% of the patients had excessive daytime sleepiness (ESS > 10) with themedian ESS of the participants was 10.0.There was no statistically significant correlation between the ESS and each of serum urea, serum creatinine, and eGFR. Conclusion:Excessive daytime sleepiness is common among CKD patients with a prevalence of 56% that may affect their quality of life.