Background : there are many causes involved recently to explain the mechanism of chronic idiopathic urticarial or its resistant to treatment one of these is the presence of Helicobacter pylori which related to GIT infections in these patients, they may complaining it like nausea, vomiting or abdominal pain or may be asymptomatic.multiple methods could be used to confirm the diagnosis; invasive and non - invasive maneuvers the most cheap and available one is the stool antigen test from stool analysis which give real Results from the intial days of infection and used to follow up the patients. The aim of this review article is to evaluate the effect of eradication therapy for H.pylori on chronic urticarial patients Conclusion: There is significant association of Helicobacter pylori infection with chronic urticaria. Eradication of H. pylori using triple or most Recent quadrable therapy is a valid therapeutic option for patients with chronic idiopathic urticaria and positive stool antigen test.