Background:In end-stage patients when all management options have been used, will often
develop compromise of their airways as the cancer continues to progress. Endobronchial
therapy options may help to relieve some of their symptoms, allowing improvement in their
shortness of breath as they go home in combination with other palliative therapies.
Objective: To compare the safety; efficacy; and clinical outcome of endobronchialcryotherapy
combined with chemotherapy and/ or radiotherapy versus chemo-radiotherapy alone on patients
with Non-small cell lung cancer.
Patients and method(s): A prospective randomized clinical trial was carried out on 60 patients,
diagnosed as bronchogenic carcinoma non-small cell lung cancer type (NSCLC). The patients
attended the hospital in the chest department, Qena Faculty of Medicine, South Valley
University. Assessment of the patients was done and randomly assigned into two
groups.Group1, Include 30 patients subjected to chemotherapy, radiotherapy and
endobronchialcryotherapy.Group2 ,Include include 30 patients subjected to chemotherapy and
radiotherapy alone.
Result(s): There was significant response meat in symptomatology in Group (1) cryotherapy
with regard to cough (P value .000) , dyspnea (P value .000) and haemoptysis (P value .000) .
Also, from the functional point of view, in group 1 there were significant improvement to
cryotherapy was achieved in FVC(P value .000) , FEV1 (P value .000) , PEFR (P value .000)
, and 6MWT (P value .000) . However, there were no significant difference in group 2 between
the incidence of improvement in FVC , FEV1 , PEFR , and 6MWT.
Conclusion:There wasbenifical effect of combination of endobronchialcryotherapy to patients
with lung cancer plus chemo and/ or radiotherapy in the form of improved symptoms and lung
functions.