Background: Immunodeficiency disorders involve malfunction of the immune system,
resulting in infections that develop and recur more frequently, are more severe, and last longer
than usual, Impair the immune system's ability to defend the body against foreign or abnormal
cells that invade or attack it (such as bacteria, viruses, fungi, and cancer cells). As a result,
unusual bacterial, viral, or fungal infections or lymphomas or other cancers may develop.
Patients and methods: A study to detect blood stream infections was done using 100 blood
cultures obtained from 100 immunocompromised children.
Results and conclusions: The most commonly isolated are bacterial organism (40 %)the most
common bacterial isolates are klebsiella species (17 | 40 ,42.5%). Estimation of DNA damage
was done for 40 patients and 10 apparently healthy children as control subjects. The DNA
damage was detected has took the smear shape on gel electrophoresis. This was found in (12|40,
30%), (P value < 0.001) with significant difference.