Background: Diabetes Mellitus (DM) is a metabolic disorder, caused by impaired carbohydrate
metabolism makes many changes in the blood vessels affecting the response of endothelium and the
smooth muscles. Polyol pathway activation, protein non-enzymatic glycosylation and increased
ROSs(reactive oxidative species) play an important role in the complications of diabetes.Ozone
activates glucose metabolism that results in increasing content of 2,3diphosphoglycerate in erythrocytes
which provides better oxygen supply into the tissues. Patients with diabetes mellitus have the so called
glycosylated hemoglobin forming very strong bonds with oxygen, thus, inducing hypoxia and
determining the severity of the disease. That is why hypoxia control with the help of ozone therapy is
of the key importance in the course of treatment.
Conclusion: Ozone therapy appears to be an effective method for DM treatment. The reason is inozone
mechanisms when it can perform a number of processes, which provide its positive effect.