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112059

Immunohistochemical Expression of E-cadherin in Invasive Duct Carcinoma of the Breast

Article

Last updated: 27 Dec 2024

Subjects

-

Tags

Disease pathology.
Oncology and Nuclear Medicine.

Abstract

Breast cancer is the most frequent malignant tumor in women worldwide. E-Cadherin is a calcium-dependent epithelial cell adhesion molecule that is expressed at adherens junctions. Its loss may result in a poorly differentiated tumorphenotype. Cells with mutated E-cadherin demonstrate increased motility, altered organization of their actin cytoskeletonand associated with metastases, thereby providing evidence for its role as an invasion suppressor.
Objectives: Assess the prognostic value of E-cadherin expression in invasive duct carcinoma (IDC) of the breastand to evaluate its correlations with other prognostic parameters.
Materials and Methods: Immunohistochemical (IHC) E-Cadherin expression was studied in 60 IDC and the results were correlated with the clinico-pathological parameters.
Results: E-cadherin was positive in 46/60 (76.7%) of IDC; 15/60 (25%) showed strong membranous staining. A significant inverse correlation was found between E-cadherin expression and number of lymph node metastasis.
Conclusions: Loss of E-cadherin expression is a predictive of invasion and metastasis in IDC.

DOI

10.21608/svuijm.2021.112059

Keywords

breast cancer, invasive duct carcinoma, E-Cadherin

Authors

First Name

Hala S. E

Last Name

Alaa Edin

MiddleName

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Affiliation

Pathology Departments, South Valley University, Egypt

Email

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City

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Orcid

-

First Name

Seham A. R

Last Name

Ismail

MiddleName

-

Affiliation

Pathology Departments, South Valley University, Egypt

Email

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City

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Orcid

-

First Name

Ghada S.

Last Name

Osman

MiddleName

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Affiliation

Pathology Departments, South Valley University, Egypt

Email

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City

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Orcid

-

First Name

Mohamed M.

Last Name

Wahman

MiddleName

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Affiliation

Oncology Departments, South Valley University, Egypt

Email

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City

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Orcid

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First Name

Eman M. S.

Last Name

Muhammad

MiddleName

-

Affiliation

Pathology Departments, Sohag University, Egypt

Email

-

City

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Orcid

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Volume

4

Article Issue

1

Related Issue

17133

Issue Date

2021-01-01

Receive Date

2020-07-11

Publish Date

2021-01-01

Page Start

112

Page End

120

Print ISSN

2735-427X

Online ISSN

2636-3402

Link

https://svuijm.journals.ekb.eg/article_112059.html

Detail API

https://svuijm.journals.ekb.eg/service?article_code=112059

Order

16

Type

Original research articles

Type Code

1,520

Publication Type

Journal

Publication Title

SVU-International Journal of Medical Sciences

Publication Link

https://svuijm.journals.ekb.eg/

MainTitle

Immunohistochemical Expression of E-cadherin in Invasive Duct Carcinoma of the Breast

Details

Type

Article

Created At

23 Jan 2023