Abstract: Background: Cellulitis is one of the common infections causing limb swelling that should be distinguished from the other skin inflammation. One of the most common infectious diseases that are associated with liver cirrhosis and lead to high morbidity, mortality, and hospital readmissions for quick diagnosis and effective treatment. Design: A descriptive study design was used. Setting(s): This study was conducted in the medical intensive care units at Tanta hospitals. Setting: A convenience sample of eighty newly admitted patients diagnosed with an acute liver failure were included. Instruments: Cellulitis risk factors structured questionnaire was used. Results: Risk factors for cellulitis were chronic venous insufficiency (76.3%), peripheral vascular disease (61.3%), obesity (87.5%), previous cellulitis (76.3%), heart failure (47.5%), sepsis (16.3%), immune suppression (3.8%), blood sugar>180mg/dl (96.25%), age 65 yrs. (21.3%), bacteraemia (47.5%), vasopressor medications (36.3%), grade VI edema (96.25%), using elastic stoking (17.5%), fluid balance >1000 ml (25.0%) and limited range of motion (61.3%).Conclusions: Risk factors associated with occurrence of cellulitis in patients with  fulminant hepatic failure are chronic venous insufficiency, peripheral vascular disease, previous cellulitis, heart failure, sepsis, immune suppression, blood sugar>180mg/dl, age 65 yrs., using elastic stoking, fluid balance >1000 ml, and limited range of motion. Recommendations: Early identification for high-risk groups for cellulitis on acute live failure patients and early prevention can reduce risk for recurrent attack. Skin and foot care protocols should be educated and used for caring those patients.