Background: Children with Sickle Cell Anemia (SCA) undergo frequent hospitalization due to painful crises, this affects their quality of life also, and it has adverse social and economic consequences. Purpose was to examine the effect of application of the PRECEDE-PROCEED planning model on the quality of life for children with sickle cell anemia. A Quasi experimental design was utilized. Setting: It was conducted at Pediatric Hematology Unit and Pediatric Hematology Outpatient Clinic at EL-Menoufia University Hospital. Sample purposive sample included 31 children diagnosed with SCA at previously mentioned settings. Two instruments used for data collection: A structured interview Precede questionnaire sheet developed by the investigator and pediatric quality of Life Scales. Results of this study showed that, the majority of studied children had Poor quality of life on pretest meanwhile two thirds of them and three quarters respectively, had moderate quality of life on post and follow up tests. Conclusion: children with SCA who received PRECEDE-PROCEED planning model had better QOL on post and follow up tests. Recommendation: integrating of PRECEDE-PROCEED planning model into the daily routine care at all pediatric hematology units.