Background: The use of simulation as a learning modality for children with epilepsy supporting caregivers to manage seizure has the potential to positively impact them to function better and helps caregivers to practice and manage stressful events in actual situation. Purpose: The purpose of the study was to evaluate the effect of simulation training on seizure management and anxiety level among mothers of children with epilepsy. Research Design: A quasi experimental design was used. Setting: It was conducted in  Pediatric Medical Department, Pediatric outpatient clinic and the general lab in Pediatric Nursing Department, Faculty of Nursing, Menoufia University. Sample: Purposive sample of 60 mothers admitted with their children having epilepsy at the previously mentioned settings. Instruments: Three data collection instruments were used: Structured Interview Questionnaire sheet, Structured Observational Checklist to assess mothers' performance and Hamilton Anxiety Rating Scale (HAM-A). Results: the result of this study showed that mothers had higher level of knowledge (21.3±1.8 post intervention) Vs (4.5±1.2 pre intervention) and practices (satisfactory performance was found between 98.3% on post intervention compared to none on pre intervention So, there were very highly statistically significant differences between mothers' anxiety level on post intervention compared to pre intervention. Conclusion: It was concluded that implementation of simulation training program improved mothers' knowledge and practices about epilepsy on post intervention than on pre intervention. Also, it contributed to lower the levels of anxiety between mothers on post intervention than pre intervention. Recommendation: Integrating simulation training into Pediatrics department is important to improve caregivers' knowledge and practice regarding their management of children having epilepsy