Background: Persons with disabilities represent a significant portion of the world's population, and they are part of every community. Information on reproductive health is often inaccessible to them. The purpose of this study was to investigate the effect of nursing intervention on sexual and reproductive health knowledge among adolescent females with educable intellectual disabilities. Design: A quasi- experimental research design was utilized (pretest–posttest test). Sample: Twenty adolescent females with an educable intellectual disability were enrolled in the study. Instrument: Two instruments were used. An interview questionnaire was developed to collect information about social characteristics. Second instrument was developed to assess knowledge of adolescent females having educable intellectual disability about reproductive health. Results: significant difference between the girls' pre, post intervention regarding their knowledge about female reproductive system (P value < 0.001) Pre 20 (100%) And post3 (15%). Conclusion: The present study concluded that the educational guidelines had a positive effect on the awareness of adolescent females with educable intellectual disability regarding reproductive health. Recommendation: Further studies should be conducted on the reproductive health care needs of adolescents with disabilities.