Background: Women with gynecological malignancies often experience health problems associated with their disease process or from the cancer directed treatment modalities. The purpose of the study was to assess the health problems caused by gynecological malignancies treatments. Methods: A descriptive cross sectional research design was utilized. Sample: A purposive sample of 180 women with gynecological malignancies was selected. Setting: The study was carried out in Menoufia Clinical Oncology Hospital. Instruments: A structured interviewing questionnaire, anthropometric assessment measures, checklist regarding health problems affecting the women received gynecological malignancies treatments were used. Results: the study findings revealed that all the study participants (100.0%) suffered from health problems caused by gynecological malignancies treatments. The majority of these health problems started during the treatment period and some of these problems had long term effect that extended after the treatment (83.8%). Conclusion: Gynecological malignancies treatments caused a wide variety of health problems and affected all body systems negatively. Recommendations: Ongoing health education for the patients receiving gynecological malignancies treatments regarding the health problems that may be caused by the treatment and the ways to alleviate it.