Burn injuries still negatively affect the varied aspects of life such as physical performance and quality of life. Major burn has long term impact on physical, psychological and social wellbeing. The purpose of the present study is to evaluate the effect of multimedia self-care strategy on functional outcomes among patients with burn. Design: A quasi experimental research design was utilized. Setting: The study was conducted in Burn Unit at Menoufia University Hospital (Emergency Hospital), Menoufia governorate, Egypt. Sample: A purposive sample of 60 adult patients with burn (30 patients in the study group and 30 in the control group). Two instruments were used in data collection Instrument one was a Structured Interviewing Questionnaire Instrument two was World Health Organization of Quality of Life Brief (WHOQOL-Brief). Results: After intervention of multimedia self-care strategy for study group, the mean score of all domains of quality of life improved from 44.67 ± 19.36 to 66.63 ± 11.89  for physical health , 38.47 ± 17.16 to 67.40 ± 15.13 for psychological health , 51.93 ± 21.64 to 64.97 ± 16.81 for social relation and 53.03 ± 18.81 to 68.70 ± 12.50 for environmental aspect  with statistically significant (P<0.001). But the changes in the quality of life of the patients in the control group were not statistically significant (P>0.05). Conclusion: The multimedia self-care strategy for burn patients improved quality of life outcomes among patients with burn. Recommendation: A multimedia self-care strategy should be developed and made available for each patient with burn to increase patient's knowledge, decrease strain and improve coping skills and quality of life.