:    Patients with HCV face numerous emotional and psychosocial stressors that have a significant effect on their well-being.  The purpose of the present study was to determine the correlation between the level of liver function enzymes, depression and anxiety among patients with hepatitis C virus.A descriptive correlational design was used to achieve the purpose of the study. The studywas carried out on the   Hepatology Ward and Medical Ward at Benha University Hospital, which is affiliated to the Ministry of Health.A convenient sample of 100 patients with hepatitis C virus were selected from the above setting. Two instruments were used. A structured interview questionnaire was used to collect data about socio demographic and clinical characteristics of the studied subjects. Hospital anxiety and depression Likert scale was used to measure anxiety and depression among the studied sample.The study revealed that more than three quarters of the patients (78.0%) had severe anxiety, nearly half of the patients (46.0%) had moderate depression. There were significant positive correlations between level of liver enzyme (ALT) and both anxiety and depression. Also, there were positive significant correlations between liver enzyme (AST) and both depression and anxiety.Conclusions: There were positive significant correlations between levels of liver function enzymes (ALT and AST) and levels of depression and anxiety among patients with hepatitis C virus. Recommendations: Stress management and assertiveness training programs should be provided to patients with hepatitis C relieve their psychological problems, normalize the level of liver enzymes and enhance their coping pattern