Recent research studies have shown that, stigma against people with mental illness is universal. Stigmatized individuals have been found to face a variety of social and emotional consequences including social withdrawal, lowered self-esteem and increased levels of negative affect.  This study was a descriptive correlational. Therefore, the purpose of this study was to identify the relationship between internalized stigma, self-esteem and loneliness among mentally ill patients. The study was conducted in inpatient ward of Benha Mental Health Hospital. Four instruments were used for collecting the data, socio-demographic and clinical data sheet, Internalized Stigma of Mental Illness Scale, Rosenberg self-esteem scale and UCLA loneliness scale. A convenient sample of 100 psychiatric patients was recruited in this study. The main results revealed that, there were negative correlation between internalizing stigma and self-esteem and show positive correlation with loneliness among studied subjects. The study recommended that there is an urgent need for developing strategies to fight internalized stigma associated with mental illness.