: Emotional intelligence affects working relationships. In adequate self-efficacy could lead to poor performance. The purpose of this study was to explore the relationship between emotional intelligence and self-efficacy among psychiatric-mental health nurses in clinical practice. Setting and sample type: This study was conducted at Benha Psychiatric-Mental Health Hospital. A convenient sample of 150 nurses working in different departments was chosen. Research design: A descriptive correlational research design was utilized in this study to be achieving the purpose of this study. Instruments: one Instrument consisted of three parts were used in data collection. Part one: Social characteristics of nurses. Part two: Nurses' emotional intelligence liker scale. Part three: self-efficacy likert scale. Results 65.2% of nurses had a high level of emotional intelligence and 51.1% had high level of self-efficacy. Conclusion: Study concluded that there was a positive correlation between the overall score of self-efficacy & emotional intelligence. Recommendations: Role play and role models are needed to increase self-awareness and social communication skills for nurses in the workplace. In addition, nursing research should focus on the factors that influence on emotional intelligence and self-efficacy of nurses at clinical practice.