The purpose for the study was to evaluate the effect of designed nursing education on awareness of patients receiving head and neck radiation therapy. Setting: The study was carried out at the Outpatient Clinics of Clinical Oncology Department and Radiotherapy Unit in Menoufia University Hospital. Subjects: A consecutive sample of 100 patients of both sexes with head and neck cancer patients receiving external radiation was selected and randomly assigned alternatively and randomly into two equal groups, 50 patients for each group. Instruments: Structured interview scheduale, includes: three parts as following: Part one: patient's Sociodemographic data, Part two: Medical data, Part three: Patient's knowledge which contains knowledge about head and neck cancer and knowledge about radiotherapy. Results: It is revealed that the mean ages for the study group was 49.12±11.25 years and control group 48.24±10.45 years. There is a significant improvement in the total knowledge score among study group than control group at post intervention regarding. Conclusion: The total knowledge score among study group (group I) was significantly higher than control group (group II) after the designed nursing intervention. Recommendation: The designed nursing intervention program should be carried out for patients with head and neck cancer at radiotherapy unit in oncology department .A colored booklet about this intervention should be prepared and distributed among nurses working at radiotherapy unit in Oncology Department.